Structural Bioinformatics, 2ed
Exclusively distributed by Star Educational Books Distributors
The first edition of Structural Bioinformatics was the first major effort to show the application of the principles and basic knowledge of the larger field of bioinformatics to questions focusing on macromolecular structure, such as the prediction of protein structure and how proteins carry out cellular functions, as well as show how the application of bioinformatics to these life science issues can improve health care by accelerating drug discovery and development. Designed primarily as a reference, the first edition nevertheless saw widespread use as a textbook in graduate and undergraduate university courses dealing with the theories and associated algorithms, resources, and tools used in the analysis, prediction, and theoretical underpinnings of DNA, RNA, and proteins.
Section I Data Collection, Analysis, And Visualization.
1 Defining Bioinformatics And Structural Bioinformatics
2 Fundamentals Of Protein Structure
3 Fundamentals Of Dna And Rna Structure
4 Computational Aspects Of High-Throughput Crystallographic Macromolecular Structure Determination
5 Macromolecular Structure Determination By Nmr Spectroscopy
6 Electron Microscopy In The Context Of Structural Systems Biology
7 Study Of Protein Three-Dimensional Structure And Dynamics Using Peptide Amide Hydrogen/ Deuterium Exchange Mass Spectrometry (Dxms) And Chemical Cross-Linking With Mass Spectrometry To Constrain Molecular Modeling
8 Search And Sampling In Structural Bioinformatics
9 Molecular Visualization
Section II Data Representation And Databases.
10 The Pdb Format, Mmcif Formats, And Other Data Formats
11 The Worldwide Protein Data Bank
12 The Nucleic Acid Database
13 Other Structure-Based Databases
Section III Data Integrity And Comparative Features.
14 Structural Quality Assurance
15 The Impact Of Local Accuracy In Protein And Rna Structures: Validation As An Active Tool
16 Structure Comparison And Alignment
17 Protein Structure Evolution And The Scop Database
18 The Cath Domain Structure Database
Section IV Structural And Functional Assignment.
19 Secondary Structure Assignment
20 Identifying Structural Domains In Proteins
21 Inferring Protein Function From Structure
22 Structural Annotation Of Genomes
23 Evolution Studied Using Protein Structure
Section V Macromolecular Interactions.
24 Electrostatic Interactions
25 Prediction Of Protein--Nucleic Acid Interactions
26 Prediction Of Protein--Protein Interactions From Evolutionary Information
27 Docking Methods, Ligand Design, And Validating Data Sets In The Structural Genomics Era
Section VI Structure Prediction.
28 Casp And Other Community-Wide Assessments To Advance The Field Of Structure Prediction
29 Prediction Of Protein Structure In 1d: Secondary Structure, Membrane Regions, And Solvent ACCESSIBILITY
30 Homology Modeling
31 Fold Recognition Methods
32 De Novo Protein Structure Prediction: Methods And Application
33 Rna Structural Bioinformatics
Section VII Therapeutic Discovery.
34 Structural Bioinformatics In Drug Discovery
35 B-Cell Epitope Prediction
Section VIII Future Challenges.
36 Methods To Classify And Predict The Structure Of Membrane Proteins
37 Protein Motion: Simulation
38 The Significance And Impacts Of Protein Disorder And Conformational Variants
39 Protein Designability And Engineering
40 Structural Genomics Of Protein Superfamilies