Voet's Biochemistry, Adapted ed 2021

Donald Voet, Judith G. Voet

ISBN: 9789354243820

1560 pages

Exclusively distributed by CBS Publishers & Distributors 


The “Gold Standard” in Biochemistry text books. Biochemistry 4e, is a modern classic that has been thoroughly revised. Don and Judy Voet explain biochemical concepts while offering a unified presentation of life and its variation through evolution. It incorporates both classical and current research to illustrate the historical source of much of our biochemical knowledge.

Guide to Media Resources


Part I Introduction and Background

Chapter 1 Life

1. Prokaryotes

2. Eukaryotes

3. Biochemistry: A Prologue

4. Genetics: A Review

5. The Origin of Life

6. The Biochemical Literature


Chapter 2 Aqueous Solutions

1. Properties of Water

2. Acids, Bases, and Buffers


Chapter 3 Thermodynamic Principles: A Review

1. First Law of Thermodynamics: Energy Is Conserved

2. Second Law of Thermodynamics: The Universe Tends Toward Maximum Disorder

3. Free Energy: The Indicator of Spontaneity

4. Chemical Equilibria

Appendix: Concentration Dependence of Free Energy


Part II Biomolecules

Chapter 4 Amino Acids

1. The Amino Acids of Proteins

2. Optical Activity

3. “Nonstandard” Amino Acids


Chapter 5 Nucleic Acids, Gene Expression, and Recombinant DNA Technology

1. Nucleotides and Nucleic Acids

2. DNA Is the Carrier of Genetic Information

3. Double Helical DNA

4. Gene Expression and Replication: An Overview

5. Molecular Cloning


Chapter 6 Techniques of Protein and Nucleic Acid Purifications

1. Protein Isolation

2. Solubilities of Proteins

3. Chromatographic Separations

4. Electrophoresis

5. Ultracentrifugation

6. Nucleic Acid Fractionation


Chapter 7 Covalent Structures of Proteins and Nucleic Acids

1. Primary Structure Determination of Proteins

2. Nucleic Acid Sequencing

3. Chemical Evolution

4. Bioinformatics: An Introduction

5. Chemical Synthesis of Polypeptides

6. Chemical Synthesis of Oligonucleotides


Chapter 8 Three-Dimensional Structures of Proteins

1. Secondary Structure

2. Fibrous Proteins

3. Globular Proteins

4. Protein Stability

5. Quaternary Structure

Appendix: Viewing Stereo Pictures


Chapter 9 Protein Folding, Dynamics, and Structural Evolution

1. Protein Folding: Theory and Experiment

2. Folding Accessory Proteins

3. Protein Structure Prediction and Design

4. Protein Dynamics

5. Conformational Diseases: Amyloids and Prions

6. Structural Evolution


Chapter 10 Hemoglobin: Protein Function in Microcosm

1. Hemoglobin and Myoglobin Function

2. Structure and Mechanism

3. Abnormal Hemoglobins

4. Allosteric Regulation

Appendix: Derivation of Symmetry Model Equations


Chapter 11 Sugars and Polysaccharides

1. Monosaccharides

2. Polysaccharides

3. Glycoproteins


Chapter 12 Lipids and Membranes

1. Lipid Classification

2. Properties of Lipid Aggregates

3. Biological Membranes

4. Membrane Assembly and Protein Targeting

5. Lipoproteins


Part III Mechanisms of Enzyme Action

Chapter 13 Introduction to Enzymes

1. Historical Perspective

2. Substrate Specificity

3. Coenzymes

4. Regulation of Enzymatic Activity

5. A Primer of Enzyme Nomenclature


Chapter 14 Rates of Enzymatic Reactions

1. Chemical Kinetics

2. Enzyme Kinetics

3. Inhibition

4. Effects of pH

5. Bisubstrate Reactions

Appendix: Derivations of Michaelis–Menten Equation Variants


Chapter 15 Enzymatic Catalysis

1. Catalytic Mechanisms

2. Lysozyme

3. Serine Proteases

4. Drug Design


Part IV Metabolism

Chapter 16 Introduction to Metabolism

1. Metabolic Pathways

2. Organic Reaction Mechanisms

3. Experimental Approaches to the Study of Metabolism

4. Thermodynamics of Phosphate Compounds

5. Oxidation–Reduction Reaction

6. Thermodynamics of Life


Chapter 17 Glycolysis

1. The Glycolytic Pathway

2. The Reactions of Glycolysis

3. Fermentation: The Anaerobic Fate of Pyruvate

4. Metabolic Regulation and Control

5. Metabolism of Hexoses Other than Glucose


Chapter 18 Glycogen Metabolism

1. Glycogen Breakdown

2. Glycogen Synthesis

3. Control of Glycogen Metabolism

4. Glycogen Storage Diseases


Chapter 19 Signal Transduction

1. Hormones

2. Heterotrimeric G Proteins

3. Tyrosine Kinase–Based Signaling

4. The Phosphoinositide Cascade


Chapter 20 Transport through Membranes

1. Thermodynamics of Transport

2. Kinetics and Mechanisms of Transport

3. ATP-Driven Active Transport

4. Ion Gradient–Driven Active Transport

5. Neurotransmission


Chapter 21 Citric Acid Cycle

1. Cycle Overview

2. Metabolic Sources of Acetyl-Coenzyme A

3. Enzymes of the Citric Acid Cycle

4. Regulation of the Citric Acid Cycle

5. The Amphibolic Nature of the Citric Acid Cycle


Chapter 22 Electron Transport and Oxidative Phosphorylation

1. The Mitochondrion

2. Electron Transport

3. Oxidative Phosphorylation

4. Control of ATP Production


Chapter 23 Other Pathways of Carbohydrate Metabolism

1. Gluconeogenesis

2. The Glyoxylate Cycle

3. Biosynthesis of Oligosaccharides and Glycoproteins

4. The Pentose Phosphate Pathway


Chapter 24 Photosynthesis

1. Chloroplasts

2. Light Reactions

3. Dark Reactions


Chapter 25 Lipid Metabolism

1. Lipid Digestion, Absorption, and Transport

2. Fatty Acid Oxidation

3. Ketone Bodies

4. Fatty Acid Biosynthesis

5. Regulation of Fatty Acid Metabolism

6. Cholesterol Metabolism

7. Eicosanoid Metabolism: Prostaglandins, Prostacyclins, Thromboxanes, Leukotrienes, and Lipoxins

8. Phospholipid and Glycolipid Metabolism


Chapter 26 Amino Acid Metabolism

1. Amino Acid Deamination

2. The Urea Cycle

3. Metabolic Breakdown of Individual Amino Acids

4. Amino Acids as Biosynthetic Precursors

5. Amino Acid Biosynthesis

6. Nitrogen Fixation


Chapter 27 Energy Metabolism: Integration and Organ Specialization

1. Major Pathways and Strategies of Energy Metabolism: A Summary

2. Organ Specialization

3. Metabolic Homeostasis: Regulation of Appetite, Energy Expenditure, and Body Weight

4. Metabolic Adaptation


Chapter 28 Nucleotide Metabolism

1. Synthesis of Purine Ribonucleotides

2. Synthesis of Pyrimidine Ribonucleotides

3. Formation of Deoxyribonucleotides

4. Nucleotide Degradation

5. Biosynthesis of Nucleotide Coenzymes


Part V Expression and Transmission of Genetic Information

Chapter 29 Nucleic Acid Structures

1. Double Helical Structures

2. Forces Stabilizing Nucleic Acid Structures

3. Supercoiled DNA


Chapter 30 DNA Replication, Repair, and Recombination

1. DNA Replication: An Overview

2. Enzymes of Replication

3. Prokaryotic Replication

4. Eukaryotic Replication

5. Repair of DNA

6. Recombination and Mobile Genetic Elements

7. DNA Methylation and Trinucleotide Repeat Expansions


Chapter 31 Transcription

1. The Role of RNA in Protein Synthesis

2. RNA Polymerase

3. Control of Transcription in Prokaryotes

4. Post-Transcriptional Processing


Chapter 32 Translation

1. The Genetic Code

2. Transfer RNA and Its Aminoacylation

3. Ribosomes

4. Control of Eukaryotic Translation

5. Post-Translational Modification

6. Protein Degradation


Chapter 33 Viruses: Paradigms for Cellular Function W-1

1. Tobacco Mosaic Virus W-3

2. Icosahedral Viruses W-8

3. Bacteriophage W-20

4. Influenza Virus W-40


Chapter 34 Eukaryotic Gene Expression

1. Chromosome Structure W-53

2. Genomic Organization W-68

3. Control of Expression W-83

4. Cell Differentiation W-121


Chapter 35 Molecular Physiology

1. Blood Clotting W-165

2. Immunity W-179

3. Motility: Muscles, Vesicle Transport, Cilia, and Flagella W-211


Index I-1 and WI-1